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Imagine
Entering a laboratory in a building
A beating heart, a metabolizing liver, and breathing lungs
…
These “millimeter-scale” human organs
In a palm-sized chip
After 2-3 weeks, it can be conceived.
This isn’t a scene from a sci-fi movie.
It is Professor Gu Zhongze’s team from Southeast University
More than ten years of research results
“Organ Chips”
In the recent
Southeast University Organ Chip Institute
High-level construction promotion meeting
“Organ Chip Building”Unveiling
Announced to settle in Nanjing Jiangbei New District
01
Human “organ chip”
A building is all “done”
Human “organ chip” technology is a key core technology that needs to be mastered urgently in my country’s biomedicine field.What is a human “organ chip”?
That is: a microphysiological system constructed outside the human body through the cross-integration of cutting-edge technologies such as stem cells, biomaterials, and nanoprocessing.
According to Gu Zhongze, director of the Southeast University Organ Chip Research Institute and professor of Southeast University, the functions of human “organ chips” are the same as those of human organs. Therefore, the research team can use “organ chips” to conduct experiments such as drug screening and drug efficacy evaluation.
The “Organ Chip Building” unveiled this time is located in Nanjing Jiangbei New District, where the biomedical industry is concentrated. In the building, basic research, technology development, talent training, etc. can be carried out, and it will also attract a number of companies to settle in and carry out application demonstrations and industrial transformation of ” organ chips “.
At present, the physical construction of the “Organ Chip Building” has been completed, and it is expected that basic functions can be put into use before the end of this year.
The first national standard for “organ chip”
Dongda took the lead in formulating
In addition to scientific research carriers, Southeast University is also continuing to make efforts in the field of “organ chip” technical standards.
Not long ago, China’s first national standard in the field of “organ chips” “General Technical Requirements for Skin Chips” (GB/T44831-2024) was officially released. The standard was drafted by Professor Gu Zhongze’s team and participated in by Nanjing Food and Drug Supervision and Inspection Institute and Nanjing Metrology Supervision and Inspection Institute.
“Skin chip” is a miniature cell and tissue culture device generated using in vitro microfluidic chips. It can simulate the biochemical and physiological characteristics of the skin and is expected to become an effective tool for toxicology testing, drug screening, and cosmetic evaluation.
The formulation of the “General Technical Requirements for Skin Chips” marks an important step forward in my country’s standardization of organ chips. It mainly stipulates the definition of relevant terms for skin chips, the appearance, cell sources, component performance, and technical requirements for biological performance of skin chips, and is applicable to the design, production, and testing of skin chip products using microfluidic chips as carriers.
In the future, “skin chips” are expected to partially replace the existing simple two-dimensional cell culture experiments, animal experiments, and artificial skin experiments, and become the most cutting-edge and powerful evaluation standard and experimental tool for skin-related in vitro evaluation.03
The first “center” in the country
Digging Deeply into the “Golden Mine” of University Scientific Research
Currently, the team of Professor Gu Zhongze of Southeast University has settled in the transformation platform of Nanjing Biomedicine Center . This platform has a “big background”.
In order to promote the transformation of scientific research results in colleges and universities, this year, the Ministry of Education and Jiangsu Province signed a cooperation agreement to jointly build the first national regional technology transfer and transformation center for colleges and universities, and the first batch of three major industrial directions were identified: biomedicine, information and communications, and advanced materials.
Among them, the transformation platform of Nanjing Biomedicine Branch Center is located in Nanjing Jiangbei New District.
At present, all construction work of the sub-center has been fully carried out.
➩ On the one hand, we “go global” and visit universities across the country to actively communicate and connect with the needs of scientific research transformation. We have established a regular communication mechanism with 25 universities across the country.
➩ On the other hand, “Please come in”, we plan to set up 18 functional sub-platforms to create a full-chain technical support and guarantee system from university scientific research output, concept verification, pilot maturation to small-batch trial production.
It is particularly worth mentioning that the sub-center will also regularly collect technical needs from leading technology companies, and the companies and participating universities will jointly select and answer questions, and use methods such as “enterprises post the list and universities answer the questions” to match needs and projects and carry out collaborative research between schools and enterprises.
In the future, the branch center also plans to form a technology transfer and transformation team of about 200 people to help university teams overcome various difficulties from laboratories to production lines, allowing them to achieve technology transformation without leaving the park and produce more cutting-edge innovative products.
